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About Lab

> Introduction > About Lab

Mass Spectrometry and Systems Biology

Often, a multitude of biochemical responses are triggered in order to overcome or counteract genetic/environmental perturbation. In addition, the intensity and the time lag for such responses reflect the biochemical network that is laid out by the genetic and structural constraints of a given biological system. We want to study which metabolic rescue mechanisms are triggered in response to various genetic and environmental stimuli (e.g. disease, nutritional stress) and how the metabolic modulation is related.

Here, we apply various types of mass-spectrometry platforms and bioinformatics approaches to unveil & link multi-layered molecular constituents, metabolite and protein to the relevant metabolic physiology. We hope the investigation can facilitate comprehensive understanding of disease mechanism, discover novel biomarkers, therapeutic compounds, and provide roadmap to re-construct newly designed microorganism for valuable compounds.