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Research

> Introduction > Research

1. Clinical Metabolomis

 

One of our researches is focused on determining the metabolic causality induced by various types of human disease.  By examining the modulation of broad range of small molecules, “metabolites” (Metabolomics) and proteins (Proteomics), we aim at understanding the biochemical mechanistics and metabolic phenotypes of such diseases as neurodegenerative disease, kidney disease, diabetics, and obesity. Further, we hope to develop diagnostic and prognostic biomarker, pharmacological and molecular approaches to treating human disease.


2. Microbial Metabolomics

 

Microbe is very first target of many scientific researches as model organism of more complex biological system (e.g. animals and plants). In addition, microorganism has been attractive resources which can produce biologically-functional compounds (e.g. prototypes of drugs, bioactive compounds), and industrially-valuable materials. In our lab, we utilize Chlamydomonas, a unicellular alga that is very well suited for such complex studies: it is a robust organism that occurs naturally in various environments, its genome is sequenced, and genetic tools and mutant and RNAi strains are available through the Chlamydomonas research community. It is biochemically related to other Eukaryotes like yeast but it also shares biochemical relationships to higher plants, like a chloroplast and starch synthesis. We aim at exploiting a variety of cutting-edge technologies in mass spectrometry and statistics to identify and quantify large metabolic networks for both metabolites and soluble enzymes.


3. Food Science

We are also interested at metabolomics-based food research in which we explore novel bioactive compounds from natural product, assess food safety, and quality using high-throughput mass-spectrometry analysis. 
4. Others

 

We are open to your own nice idea whichever has "metabolism" in it. Bring your idea to "Systems"